Seminar

Title:　　 　　 Cancer and E3 Ubiquitin Ligase

Speaker:　　Dr. Xu Zhi

University of Central Florida, USA

Host:　　　　 Prof. Yingli Sun

Time:　  　  10:00-11:00am, July 15，2013

Location:　 First-floor seminar hall, Beijing Institute of Genomics, CAS

Abstract:  E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins by catalyzing the ubiquitination of a variety of biologically significant protein substrates, therefore, play an essential role in the regulation of many biologic processes. Increasing amounts of evidence strongly suggest that the abnormal regulation of some E3 ligases is involved in cancer development. Furthermore, some E3 ubiquitin ligases are frequently over-expressed in human cancers, which correlate well with increased chemo-resistance and poor clinic prognosis. In this seminar, Dr. Xu Zhi will present her excellent research on E3 ubiquitin ligase RNF126, WWP1 and cancer.