杨运桂YANG Yungui
所长，研究员
| 电子邮件： | ygyang@big.ac.cn |
|---|
学习经历：
1991年9月-1995年8月 复旦大学生命科学院 微生物学 理学学士学位
1995年9月-2000年8月 中国科学院上海药物所/上海生物工程研究中心 理学博士学位
工作经历：
2023年8月至今，中国科学院北京基因组研究所（国家生物信息中心），所长
2020年12月-2023年7月，中国科学院北京基因组研究所（国家生物信息中心），副所长
2019年11月至今，中国科学院北京基因组研究所（国家生物信息中心），研究员
2008年11月-2019年11月，中国科学院北京基因组研究所，研究员
2005年11月-2008年11月，英国癌症研究署，博士后
2000年9月-2005年11月，法国世界卫生组织国际癌症研究署，博士后/Staff Scientist
学术兼职：
RNA Biology 编委（2018-）
Genomics, Proteomics & Bioinformatics (Beijing) 编委(2010-)，副主编（2015-）
IUBMB Life 编委（2020-）
中国生物化学与分子生物学RNA专业委员会副主任（2016-）
中国科学院北京基因组研究所第四届学术委员会主任（2017-）
中国生物化学与分子生物学会第十二届理事会常务理事兼副秘书长（2018-）
获奖及荣誉：
2012 中国科学院大学-BHPB 导师科研奖
2013 中国科学院青年科学家国际合作奖
2013 中国科学院朱李月华优秀教师奖
2015 中国科学院特聘研究员
2016 国家“杰出青年”科学基金获得者
2017 Sanofi-Cell Research优秀研究文章奖
2017 中国生命科学研究领域十大进展
2018 第三届中国科协优秀科技论文
2018 中国科学院优秀导师奖
2018 享受国务院政府特殊津贴专家
2019年 谈家桢生命科学创新奖
2019年 中国科学院优秀导师奖
2020年 欧洲科学院院士（Member of the Academia Europaea）
RNA表观遗传学特征、调控和功能
SELECTED PUBLICATIONS (*CORRESPONDING-AUTHOR EQUIVALENT)
1. Chen Yu-Sheng #, Lu Shuaiyao #, Zhang Bing #, Du Tingfu, Li Wen-Jie, Lei Meng, Zhou Yanan, Zhang Yong, Liu Penghui, Sun Yong-Qiao, Zhao Yong-Liang, Yang Ying*, Peng Xiaozhong*, Yang Yun-Gui*. Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome, Protein & Cell, 2021. https://doi.org/10.1007/s13238-021-00861-8
2. Zhang Ting#, Yang Ying#, Xiang Zichun#, Gao Chun-Chun#, Wang Wenjing, Wang Conghui, Xiao Xia, Wang Xing, Qiu Wei-Nan, Li Wen-Jie, Ren Lili, Li Mingkun, Zhao Yong-Liang, Chen Yu-Sheng*, Wang Jianwei*, and Yang Yun-Gui*. N6- methyladenosine regulates RNA abundance of SARS-CoV-2, Cell Discovery, 2021, 7(1): 7.
3. Mu Haiyuan #, Zhang Ting #, Yang Ying #, Zhang Danru, Li Junhong, Yue Liang, Gao Dengfeng, Shi Bingbo, Han Yue, Zhong Liang, Chen Xinze, Wang Zhen-Bo, Lin Zhen, Tong Minghan, Sun Qing-Yuan, and Gao Jie, Yang Yun-Gui*, Han Jianyong*. METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice. Cell Death and Differentiation. accepted
4. Wu Gongwei# *, Suo Caixia#, Yang Ying, Shen Shengqi, Sun Linchong, Li Shi-Ting, Zhou Yingli, Yang Dongdong, Wang Yan, Cai Yongping, Wang Nana, Zhang Huafeng, Yang Yun-Gui*, Cao Jie* & Gao Ping*. MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation, EMBO Reports, 2021, e51519.
5. Li Yaqian#, Zhang Qing-Yang#, Sun Bao-Fa#, Ma Yidi, Zhang Ye, Wang Min, Ma Congcong, Shi Honghui, Sun Zhijing, Chen Juan, Yang Yun-Gui*, Zhu Lan*. Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse, Nature Communications, 2021, 12(1): 87.
6. Chen Yu-Sheng#, Yang Wen-Lan#, Zhao Yong-Liang, Yang Yun-Gui*. Dynamic transcriptomic m5C and its regulatory role in RNA processing, WIREs RNA, 2021, e1639, doi: 10.1002/wrna.1639.
7. Qiu Weinan#, Zhang Qingyang#, Zhang Rui, Lu Yangxu, Wang Xin, Tian Huabin, Yang Ying, Gu Zijuan, Gao Yanan, Yang Xin, Cui Guanshen, Sun Bao-Fa, Peng Yanan, Deng Hongyu, Peng Hua, Yang Angang, Yang Yun-Gui*, Yang Pengyuan *. N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA, Nature Communications, 2021, 12:1582, doi: 10.1038/s41467-021-21904-y.
8. Yao Yingpeng#, Yang Ying#, Guo Wenhui#, Xu Lifan#, You Menghao, Zhang Yi-Chang, Sun Zhen, Cui Xiao, Yu Guotao, Qi Zhihong, Liu Jingjing, Wang Fang, Liu Juanjuan, Zhao Tianyan, Ye Lilin*, Yang Yun-Gui* & Yu Shuyang*. METTL3-dependent m6A modification programs T follicular helper cell differentiation, Nature Communications, 2021, 12(1): 1333, doi: 10.1038/s41467-021-21594-6.
9. Shi Boyang#, Zhang Jinsong#, Heng Jian#, Gong Jing#, Zhang Ting, Li Pan, Sun Bao-Fa, Yang Ying, Zhang Ning, Zhao Yong-Liang, Wang Hai-Lin, Liu Feng*, Zhang Qiangfeng Cliff* and Yang Yun-Gui*. RNA structural dynamics regulates early embryogenesis through controlling transcriptome fate and function, Genome Biology, 2020, 21(1): 120.
10. Han Xiao#, Wang Mengke#, Zhao Yong-Liang, Yang Ying*, Yang Yun-Gui*. RNA methylations in human cancers, Seminars in Cancer Biology, 2020, S1044-579X(20)30241-8.
11. Tang Yongyan#, Gao Chun-Chun#, Gao Ying, Yang Ying, Shi Boyang, Yu Jia-Li, Lyu Cong, Sun Bao-Fa, Wang Hai-Lin, Xu Yunyuan, Yang Yun-Gui*, and Chong Kang*. OsNSUN2-mediated 5-methylcytidine mRNA modification enhances rice adaptation to high-temperature, Developmental Cell, 2020, 53: 272-286.
12. Han Xiao#, Liu Hanchen#, Zhang Zezhong#, Yang Wenlan, Wu Chunyan, Liu Xueying, Zhang Fang, Sun Baofa, Zhao Yongliang, Jiang Guibin, Yang Yun-Gui*, Ding Wenjun*. Epitranscriptomic 5-methylcytosine profile in PM2.5-induced mouse pulmonary fibrosis, Genomics, Proteomics& Bioinformatics, 2020, 18 (1) : 41-51.
13. Chen Xin#, Li Ang#, Sun Bao-Fa#, Yang Ying#, Han Ya-Nan#, Yuan Xun#, Chen Ri-Xin, Wei Wen-Su, Liu Yanchao, Gao Chun-Chun, Chen Yu-Sheng, Zhang Mengmeng, Ma Xiao-Dan, Liu Zhuo-Wei, Luo Jun-Hang, Lyu Cong, Wang Hai-Lin, Ma Jinbiao, Zhao Yong-Liang, Zhou Fang-Jian, Huang Ying*, Xie Dan* and Yang Yun-Gui*. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs, Nature Cell Biology, 2019, 21(8): 978-990.
14. Yang Ying#, Wang Lu#, Han Xiao#, Yang Wen-Lan#, Zhang Mengmeng#, Ma Hai-Li, Sun Bao-Fa, Li Ang, Xia Jun, Chen Jing, Heng Jian, Wu Baixing, Chen Yu-Sheng, Xu Jia-Wei, Yang Xin, Yao Huan, Sun Jiawei, Lyu Cong, Wang Hai-Lin, Huang Ying, Sun Ying-Pu, Zhao Yong-Liang, Meng Anming, Ma Jinbiao*, Liu Feng*, and Yang Yun-Gui*. RNA 5-methylcytosine facilitates the maternal-to-zygotic transition by preventing maternal mRNA decay, Molecular Cell, 2019, 75(6): 1188-1202.
15. Yang Xin#, Yang Ying#, Sun Bao-Fa#, Chen Yu-Sheng#, Xu Jia-Wei#, Lai Wei-Yi#, Li Ang, Wang Xing, Bhattarai Devi Prasad, Xiao Wen, Sun Hui-Ying, Zhu Qin, Ma Hai-Li, Adhikari Samir, Sun Min, Hao Ya-Juan, Zhang Bing, Huang Chun-Min, Huang Niu, Jiang Gui-Bin, Zhao Yong-Liang, Wang Hai-Lin*, Sun Ying-Pu*, Yang Yun-Gui*. 5-methylcytosine promotes mRNA export-NSUN2 as the methyltransferase and ALYREF as an m5C reader, Cell Research, 2017, 27(5): 606-625.
16. Zhang Chunxia#, Chen Yusheng#, Sun Baofa#, Wang Lu#, Yang Ying#, Ma Dongyuan, Lv Junhua, Heng Jian, Ding Yanyan, Xue Yuanyuan, Lu Xinyan, Xiao Wen, Yang Yun-Gui* & Liu Feng*. m6A modulates haematopoietic stem and progenitor cell specification, Nature, 2017, 549(7671): 273-276.
17. Xiao Wen#, Adhikari Samir#, Dahal Ujwal#, Chen Yu-Sheng#, Hao Ya-Juan#, Sun Bao-Fa#, Sun Hui-Ying, Li Ang, Ping Xiao-Li, Lai Wei-Yi, Wang Xing, Ma Hai-Li, Huang Chun-Min, Yang Ying, Huang Niu, Jiang Gui-Bin, Wang Hai-Lin, Zhou Qi, Wang Xiu-Jie, Zhao Yong-Liang, and Yang Yun-Gui*. Nuclear m6A reader YTHDC1 regulates mRNA splicing, Molecular Cell, 2016, 61(4): 507-519）
18. Shi Zhan#, Zhang Qingyang#, Yan Huige#, Yang Ying#, Wang Pingzhang, Zhang Yixiao, Deng Zhenling, Yu Meng, Zhou Wenjing, Wang Qianqian, Yang Xi, Mo Xiaoning, Zhang Chi, Huang Jing, Dai Hui, Sun Baofa, Zhao Yongliang, Zhang Liang, Yang Yun-Gui* and Qiu Xiaoyan*. More than one antibody of individual B cells revealed by single-cell immune profiling, Cell Discovery, 2019, 5:64, doi: 10.1038/s41421-019-0137-3.
19. Jia Ruobing#, Chai Peiwei#, Wang Shanzheng#, Sun Baofa, Xu Yangfan, Yang Ying, Ge Shengfang, Jia Renbing*, Yang Yun-Gui* and Fan Xianqun*. m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation, Molecular Cancer, 2019, 18(1):161.
20. Yang Xin#, Liu Qian-Lan#, Xu Wei#, Zhang Yi-Chang#, Yang Ying, Ju Lin-Fang, Chen Jing, Chen Yu-Sheng, Li Kuan, Ren Jie*, Sun Qianwen* and Yang Yun-Gui*. m6A promotes R-loop formation to facilitate transcription termination, Cell Research, 2019, 29(12):1035-1038.
21. Malbec Lionel#, Zhang Ting#, Chen Yu-Sheng#, Zhang Ying, Sun Bao-Fa, Shi Bo-Yang, Zhao Yong-Liang, Yang Ying* and Yang Yun-Gui*. Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation, Cell Research, 2019, 29(11): 927–941.
22. Peng Junya#, Sun Bao-Fa#, Chen Chuan-Yuan#, Zhou Jia-Yi#, Chen Yu-Sheng#, Chen Hao, Liu Lulu, Huang Dan, Jiang Jialin, Cui Guan-Shen, Yang Ying, Wang Wenze, Guo Dan, Dai Menghua, Guo Junchao, Zhang Taiping, Liao Quan, Liu Yi, Zhao Yong-Liang, Han Da-Li#, Zhao Yupei*, Yang Yun-Gui* and Wu Wenming*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma, Cell Research, 2019, 29(9):725-738.
23. Peng Shiming#, Xiao Wen#, Ju Dapeng#, Sun Baofa#, Hou Nannan, Liu Qianlan, Wang Yanli, Zhao Haijiao, Gao Chunchun, Zhang Song, Cao Ran, Li Pengfei, Huang Huanwei, Ma Yongfen, Wang Yankai, Lai Weiyi, Ma Zhixiong, Zhang Wei, Huang Song, Wang Hailin, Zhang Zhiyuan, Zhao Liping, Cai Tao, Zhao Yong-Liang, Wang Fengchao, Nie Yongzhan, Zhi Gang, Yang Yun-Gui*, Zhang Eric Erquan*, Huang Niu*. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1, Science Translational Medicine, 2019, 11(488): eaau7116.
24. Wu Rong#, Li Ang#, Sun Baofa#, Sun Jian-Guang#, Zhang Jinhua#, Zhang Ting#, Chen Yusheng, Xiao Yujie, Gao Yuhao, Zhang Qingyang, Ma Jun, Yang Xin, Liao Yajin, Lai Wei-Yi, Qi Xiaolong, Wang Shukun, Shu Yousheng, Wang Hai-Lin, Wang Fengchao*, Yang Yun-Gui* and Yuan Zengqiang*. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination, Cell Research, 2019, 29(1): 23-41.
25. Yang Ying#, Hsu Phillip J.#, Chen Yu-Sheng and Yang Yun-Gui*. Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism, Cell Research, 2018, 28(6): 616-624.
26. Zhang Zeyu#, Wang Meng#, Xie Dongfang, Huang Zenghui, Zhang Lisha, Yang Ying, Ma Dongxue, Li Wenguang, Zhou Qi, Yang Yun-Gui* and Wang Xiu-Jie*. METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation, Cell Research, 2018, 28(11): 1050-1061.
27. Wang Chen-Xin#, Cui Guan-Shen#, Liu Xiuying#, Xu Kai#, Wang Meng#, Zhang Xin-Xin, Jiang Li-Yuan, Li Ang, Yang Ying, Lai Wei-Yi, Sun Bao-Fa, Jiang Gui-Bin, Wang Hai-Lin, Tong Wei-Min, Li Wei, Wang Xiu-Jie*, Yang Yun-Gui*, Zhou Qi*. Mettl3-mediated m6A modification is required for cerebellar development, PLOS Biology, 2018, 16(6):e2004880.
28. Tian Xin#, Sun Baofa#, Chen Chuanyuan#, Gao Chunchun#, Zhang Ji#, Lu Xingyu#, Wang Linchen, Li Xiangnan, Xing Yurong, Liu Ruijuan, Han Xiao, Qi Zheng, Zhang Xiaojian, He Chuan, Han Dali*, Yang Yun-Gui* and Kan Quancheng*. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018, 28(5): 597-600.
29. Xu Kai#, Yang Ying#, Feng Gui-Hai#, Sun Bao-Fa#, Chen Jun-Qing#, Li Yu-Fei, Chen Yu-Sheng, Zhang Xin-Xin, Wang Chen-Xin, Jiang Li-Yuan, Liu Chao, Zhang Ze-Yu, Wang Xiu-Jie, Zhou Qi*, Yang Yun-Gui*, Li Wei*. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation, Cell Research, 2017, 27(9):1100-1114.
30. Li Ang#, Chen Yu-Sheng#, Ping Xiao-Li, Yang Xin, Xiao Wen, Yang Ying, Sun Hui-Ying, Zhu Qin, Baidya Poonam, Wang Xing, Bhattarai Devi Prasad, Zhao Yong-Liang, Sun Bao-Fa*, Yang Yun-Gui*. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation, Cell Research, 2017, 27(3): 444-447.
31. Chen Tong#, Hao Ya-Juan#, Zhang Ying#, Li Miao-Miao#, Wang Meng, Han Weifang, Wu Yongsheng, Lv Ying, Hao Jie, Wang Libin, Li Ang, Yang Ying, Jin Kang-Xuan, Zhao Xu, Li Yuhuan, Ping Xiao-Li, Lai Wei-Yi, Wu Li-Gang, Jiang Guibin, Wang Hai-Lin, Sang Lisi, Wang Xiu-Jie*, Yang Yun-Gui*, and Zhou Qi*, m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell, 2015, 16(3): 289-301.
32. Ping Xiao-Li#, Sun Bao-Fa#, Wang Lu#, Xiao Wen#, Yang Xin, Wang Wen-Jia, Adhikari Samir, Shi Yue, Lv Ying, Chen Yu-Sheng, Zhao Xu, Li Ang, Yang Ying, Dahal Ujwal, Lou Xiao-Min, Liu Xi, Huang Jun, Yuan Wei-Ping, Zhu Xiao-Fan, Cheng Tao, Zhao Yong-Liang, Wang Xinquan, Rendtlew Danielsen Jannie M, Liu Feng*, Yang Yun-Gui*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase, Cell Research, 2014, 24(2): 177-189.
33. Zhao Xu#, Yang Ying#, Sun Bao-Fa#, Shi Yue#, Yang Xin, Xiao Wen, Hao Ya-Juan, Ping Xiao-Li, Chen Yu-Sheng, Wang Wen-Jia, Jin Kang-Xuan, Wang Xing, Huang Chun-Min, Fu Yu, Ge Xiao-Meng, Song Shu-Hui, Jeong Hyun Seok, Yanagisawa Hiroyuki, Niu Yamei, Jia Gui-Fang, Wu Wei, Tong Wei-Min, Okamoto Akimitsu, He Chuan, Rendtlew Danielsen Jannie M, Wang Xiu-Jie, Yang Yun-Gui*. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis, Cell Research, 2014, 24(12): 1403-1419.
34. Zheng Guanqun#, Dahl John Arne#, Niu Yamei#, Fedorcsak Peter, Huang Chun-Min, Li Charles J., V？gb？ Cathrine B., Shi Yue, Wang Wen-Ling, Song Shu-Hui, Lu Zhike, Bosmans Ralph P.G., Dai Qing, Hao Ya-Juan, Yang Xin, Zhao Wen-Ming, Tong Wei-Min, Wang Xiu-Jie, Bogdan Florian, Furu Kari, Fu Ye, Jia Guifang, Zhao Xu, Liu Jun, Krokan Hans E., Klungland Arne*, Yang Yun-Gui*, and He Chuan*. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility, Molecular Cell, 2013, 49(1): 18-29.
35. Gao Min#, Wei Wei#, Li Ming-Ming#, Wu Yong-Sheng#, Ba Zhaoqing, Jin Kang-Xuan, Li Miao-Miao, Liao You-Qi, Adhikari Samir, Chong Zechen, Zhang Ting, Guo Cai-Xia, Tang Tie-Shan, Zhu Bing-Tao, Xu Xing-Zhi, Mailand Niels, Yang Yun-Gui*, Qi Yijun*. Rendtlew Danielsen Jannie M, Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination, Cell Research, 2014, 24(5): 532-541.
36. Zhao Bailin#, Yang Ying#, Wang Xiaoli#, Chong Zechen, Yin Ruichuan, Song Shu-Hui, Zhao Chao, Li Cuiping, Huang Hua, Sun Bao-Fa, Wu Danni, Jin Kang-Xuan, Song Maoyong, Zhu Ben-Zhan, Jiang Guibin, Rendtlew Danielsen Jannie M., Xu Guo-Liang, Yang Yun-Gui*, Wang Hailin*. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism, Nucleic Acids Research, 2014, 42(3):1593-1605.
37. Li Ming-Ming#, Nilsen Anja#, Shi Yue#, Fusser Markus, Ding Yue-He, Fu Ye, Liu Bo, Niu Yamei, Wu Yong-Sheng, Huang Chun-Min, Olofsson Maria, Jin Kang-Xuan, Lv Ying, Xu Xing-Zhi, He Chuan, Dong Meng-Qiu, Rendtlew Danielsen Jannie M., Klungland Arne* & Yang Yun-Gui*. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics, Nature Communications, 2013, 4: 1832.
38. Gao Min#, Rendtlew Danielsen Jannie#, Wei Lei-Zhen#, Zhou Dong-Ping, Xu Qian, Li Miao-Miao, Wang Zhao-Qi, Tong Wei-Min, Yang Yun-Gui*. A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity, PLoS ONE, 2012, 7(11): e49687.
39. Adhikari Samir, Xiao Wen, Zhao Yong-Liang, and Yang Yun-Gui*. m6A: Signaling for mRNA Splicing, RNA Biology, 2016, 13(9): 756-759.
40. Yang Ying#, Sun Bao-Fa#, Xiao Wen, Yang Xin, Sun Hui-Ying, Zhao Yong-Liang, Yang Yun-Gui*. Dynamic m6A modification and its emerging regulatory role in mRNA splicing, Science Bulletin, 2015, 60(1): 21-32.
41. Klungland Arne*, Yang Yun-Gui*. Endogenous DNA damage and repair enzymes, Genomics, Proteomics & Bioinformatics, 2016, 14(3): 122-125.
42. Mi Shuangli, Klungland Arne* & Yang Yun-Gui*. Base-excision repair and beyond, Science China Life Sciences, 2016, 59(1): 89-92.
43. Yang Yun-Gui*, Qi Yijun*. RNA-directed repair of DNA double-strand breaks, DNA Repair, 2015, 32: 82-85.
44. Zhao Xu#, Yang Ying#, Sun Bao-Fa, Zhao Yong-Liang, Yang Yun-Gui*. FTO and obesity: mechanisms of association, Current Diabetes Reports, 2014, 14(5): 486.
45. Niu Yamei, Zhao Xu, Wu Yong-Sheng, Li Ming-Ming, Wang Xiu-Jie, Yang Yun-Gui*. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function, Genomics, Proteomics & Bioinformatics, 2013, 11(1): 8-17.
1. 中国科学院前沿科学重点研究， RNA甲基化表观转录组学测序新技术和新理论，2017.05-2022.04，在研，主持；
2. 中国科学院-北京协和医院合作项目, 胰腺癌新机制研究及其精准临床诊治体系建立，2017/01-2019/12，在研，主持；
3. 中以NSFC-ISF合作研究项目，解析神经发育疾病基因MeCP2和LIS1相互作用的分子机制，2017.01-2019.12，在研，主持；
4. 国家“杰出青年”科学基金，基因表达调控与表观遗传学，2017.01-2021.12，在研，主持；
5. 国家重点研发计划精准医学研究重点专项，表观基因组学检测技术研发与临床应用，2016.07-2018.12，在研，主持；
6. 战略性先导科技专项-B类, 污染物诱发核酸损伤、修复与基因突变的分子机制, 2014.07-2019.06,在研,骨干；
7. 国家自然科学基金重点项目，RNA m6A修饰甲基转移酶复合物及其表观调控因子鉴定和作用机制研究，2015.01-2019.12，在研，主持；
8. 国家自然科学基金面上项目, RNA表观遗传新机制调控DNA双链断裂修复分子机理研究，2014.01-2017.12，在研，主持；
9. 国家自然科学基金重大研究计划(集成项目)，DNA与RNA甲基化表观修饰对单倍体干细胞多能性与发育能力影响的机制研究，2014.01-2016.12，已结题，参加；
10. 科技部 973，中国人前列腺癌的表观遗传特征及调控机制，2012.01-2016.09，已结题，骨干；
11. 科技部 973，组蛋白甲基化对肺癌发生发展的作用及其机制，2011.01-2015.12，已结题，主持；
12. 国家自然科学基金面上项目，ALKBH4加双氧酶介导的细胞分裂重要功能因子去甲基化机制研究，2011.01-2013.12，已结题，主持；
13. 国家自然科学基金面上项目，DNA损伤检验点和DNA双链断裂修复途径的相互协调维持基因组稳定性的分子机理的研究，2009.01-2011.12，已结题，主持；
课题组于2008年11月成立，系统研究表观转录组调控与RNA甲基化功能机理，在拓展RNA甲基化表观转录组调控的前沿新领域合作研究中，发现人源 RNA m6A修饰甲基转移酶复合物METTL3/METTL14/WTAP(Cell Res 2014 年，为 Natl Sci Rev 研究特色论文)，揭示非编码miRNA介导的m6A甲基化位点形成的选择性机制(Cell Stem Cell 2015，入选当期封面特写报道和 Cell 出版社的研究特色论文)，参与鉴定m6A去甲基化酶ALKBH5(Mol Cell 2013，作为 RNA 生物学研究前沿热点入选 Science Editor’s Choice)和FTO(Nat Chem Biol 2011)，发现m6A修饰作为mRNA新顺式元件调控mRNA剪接和翻译功能(Cell Res 2014，为 Cell Res 研究特色论文；Mol Cell 2016，为Trends In Genetics Hotspot论文；Cell Res 2017)，揭示m6A调控造血干细胞定向分化和精子发生减数分裂机制 （Nature 2017; Cell Res 2017, 入选当期封面特写报道）；还发现了m5C修饰通过其结合蛋白ALYREF调控mRNA出核机制（Cell Res 2017, 入选当期封面特写报道）。这些结果表明RNA甲基化修饰具有可逆性并调控RNA加工代谢作用，拓展了RNA甲基化表观转录组前沿性领域，并应邀撰写多篇综述(Genom Prote Bioinfor 2013; Curr Diab Rep 2014; Sci Bull 2015; RNA Biol 2016)。
课题组研发RNA化学修饰高通量测序和分析技术，系统研究RNA甲基化及其修饰酶，阐明其功能及遗传性状（表型）和疾病关联的调控机制。
工作人员
杨莹 博士 副研究员/青促会/北京市科技新星
孙宝发 博士 副研究员/青促会
陈宇晟 特别研究助理
邱伟楠 特别研究助理
黄春敏 工程师
博士后
张丽媛, 2017
研究生
王秀芝, 2017
宋丹, 2017
张婷, 2017
韩悦, 2017
安柯, 2018
姚欢, 2018
刘倩兰, 2018
杨文兰, 2018
周佳熠, 2018
陈静, 2018
郭静云, 2018
梁承志, 2018
王兴, 2019
徐恒佶, 2019
吴盈, 2020
宋鸽鸽, 2020
姚卜飞, 2020
梁道博, 2020
马成意, 2020
已毕业研究生
高敏（博士），赵旭（博士），李明明（博士），杨莹（博士），史悦（博士），平晓丽（博士），肖文（博士），SAMIR ADHIKARI (博士) ，UJWAL DAHAL(博士)，郝亚娟（博士），黄春敏（硕士），徐倩（硕士），周东平（硕士），王文岭（硕士），廖友琦（硕士），李苗苗（硕士），金康宣（硕士），王文佳（硕士），吕英（硕士），孙慧颖（硕士）
RNA转录调控与发育及环境应答机制
合作团队绘制了首个PM2.5诱导的肺纤维化中RNA m5C图谱，发现m5C增益的上调基因可能对PM2.5诱导的小鼠肺纤维化发展至关重要，对开发PM2.5暴露相关性肺病的潜在生物标志物具有潜在价值（Han et al. Genomics Proteomics & Bioinformatics 2020）；鉴定了水稻mRNA m5C甲基转移酶OsNSUN2，构建了甲基化图谱，发现m5C修饰调控mRNA翻译效率，发现36 条件下osnsnu2突变体的叶绿体功能紊乱，导致光依赖的活性氧积累，揭示OsNSUN2介导水稻mRNA的m5C修饰，调控水稻高温适应性（Tang et al. Developmental Cell 2020）；从代表性RNA修饰（m6A、m5C等）特征规律切入，系统综述RNA甲基化参与多种癌症的致病机理(Han et al. Seminars in Cancer Biology 2020)；绘制了包含RNA四个碱基信息的斑马鱼早期胚胎发育RNA二级结构全景图谱，并发现RNA结构影响结合蛋白Elavl1a对RNA结合能力，从而调控母源mRNA稳定及降解，调节斑马鱼母源-合子转换及早期胚胎发育进程（Shi et al. Genome Biology 2020）。
