Seminar 

　　Title:  A Critical Role for Alternative RNA Splicing in EMT and Breast Cancer Progression  

　　Speaker:   Chonghui Cheng 

　　M.D., Ph.D. Assistant Professor, 

　　Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago 

　　Host:     Zhihua Zhang 

　　Time:     10: 00-11: 00 am , Aug 30, 2013 

　　Location:   First-floor seminar hall, Conference Room, BIG, CAS 

　　Abstract: Tumor metastasis is the major cause of mortality in cancer patients. A common feature of metastatic tumor cells is that they possess abnormal activation of a developmental process called epithelial-mesenchymal transition (EMT).  Our recent work demonstrates for the first time that RNA regulation at the level of alternative splicing constitutes a novel mechanism that controls EMT and breast cancer progression. We further show that the phenotypic switch of EMT is controlled by splicing factors through alternative RNA splicing regulation of its target genes. 

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　　Welcome to attend!