李翠丹----中国科学院北京基因组研究所（国家生物信息中心）

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北京市人才

李翠丹LI Cuidan

副研究员

电子邮件：	licuidan@big.ac.cn

学习经历：

2010年9月-2014年7月河北大学生物信息学专业理学学士学位
2014年9月-2019年7月中国科学院大学基因组学专业理学博士学位

工作经历：

2019年8月至2024年1月中国科学院北京基因组研究所（国家生物信息中心）助理研究员

2024年2月至今中国科学院北京基因组研究所（国家生物信息中心）副研究员

获奖及荣誉：

2022年中国科学院青年创新促进会会员

1. Li C#, Qian Q#, Yan C#, Lu M#, Li L#, Li P, Fan Z, Lei W, Shang K, Wang P, Wang J, Lu T, Huang Y, Yang H, Wei H, Han J, Xiao J, Chen F. HervD Atlas: a curated knowledgebase of associations between human endogenous retroviruses and diseases. Nucleic Acids Res. 2024 Jan 5;52(D1):D1315-D1326.

2. Li C#, Jiang X#, Yang T#, Ju Y#, Yin Z, Yue L, Ma G, Wang X, Jing Y, Luo X, Li S, Yang X, Chen F, Zhou D. Genomic Epidemiology of Carbapenemase-producing Klebsiella pneumoniae in China. Genomics Proteomics Bioinformatics. 2022 Dec;20(6):1154-1167.

3. Li C#, Yue L#, Ju Y#, Wang J#, Lu H#, Li L#, Chen M, Wang C, Li S, Liu T, Liu S, Lu T, Wang J, Hu X, Jiang C, Zhou D, Chen F. Transcriptomic analysis for the retested positive COVID-19 patients with long-term persistent SARS-CoV-2 but without symptoms in Wuhan. Clin Transl Med. 2023 Jan;13(1):e1172.

4. Li C#, Yue L#, Ju Y#, Wang J, Chen M, Lu H, Liu S, Liu T, Wang J, Hu X, Tuohetaerbaike B, Wen H, Zhang W, Xu S, Jiang C, Chen F. Serum Proteomic Analysis for New Types of Long-Term Persistent COVID-19 Patients in Wuhan. Microbiol Spectr. 2022 Dec 21;10(6):e0127022.

5. Li C#, Ma G, Yang T, Wen X, Qin C, Yue L, Jia X, Shen Y, Lu D, Wang L, Shen D, Chen F. A rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae with an untypeable blaKPC-harboured conjugative plasmid. J Glob Antimicrob Resist. 2020 Sep;22:426-433.

6. Li C as co-first author in CNCB-NGDC Members and Partners. (2024) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Res. 2024;52(D1):D18-D32.

7. Wang P#, Li C#, Yin Z, Jiang X, Li X, Mu X, Wu N, Chen F, Zhou D. Genomic epidemiology and heterogeneity of Providencia and their blaNDM-1-carrying plasmids. Emerg Microbes Infect. 2023 Dec;12(2):2275596.

8. Jia X#, Li C#, Chen F#, Li X#, Jia P#, Zhu Y, Sun T, Hu F, Jiang X, Yu Y, Hu B, Yang Q, Kang M, Liang H, Liao K, Hu L, Gu L, Jin Y, Duan Q, Zhang S, Sun Z, Huang W, He H, Shao H, Shan B, Zhuo C, Ji P, Zheng R, Li G, Xu Y, Yang Q. Genomic epidemiology study of Klebsiella pneumoniae causing bloodstream infections in China. Clin Transl Med. 2021 Nov;11(11):e624.

9. Huang H#, Ding N#, Yang T#, Li C#, Jia X#, Wang G#, Zhong J, Zhang J, Jiang G, Wang S, Zong Z, Jing W, Zhao Y, Xu S, Chen F. Cross-sectional Whole-genome Sequencing and Epidemiological Study of Multidrug-resistant Mycobacterium tuberculosis in China. Clin Infect Dis. 2019 Jul 18;69(3):405-413.

10. Li S#, Jiang X#, Li C#, Ju Y, Yue L, Chen F, Hu L, Wang J, Hu X, Tuohetaerbaike B, Wen H, Zhang W, Zhou D, Yin Z, Chen F. A blaSIM-1 and mcr-9.2 harboring Klebsiella michiganensis strain reported and genomic characteristics of Klebsiella michiganensis. Front Cell Infect Microbiol. 2022 Aug 24;12:973901.

11. Lv L#, Li C#, Zhang X#, Ding N#, Cao T#, Jia X, Wang J, Pan L, Jia H, Li Z, Zhang J, Chen F, Zhang Z. RNA Profiling Analysis of the Serum Exosomes Derived from Patients with Active and Latent Mycobacterium tuberculosis Infection. Front Microbiol. 2017 Jun 12;8:1051.

12. Zhang J#, Zhang X#, Li C#, Yue L#, Ding N, Riordan T, Yang L, Li Y, Jen C, Lin S, Zhou D, Chen F. Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells. RNA Biol. 2019 Feb;16(2):220-232.

13. Lyu L#, Zhang X#, Li C#, Yang T#, Wang J, Pan L, Jia H, Li Z, Sun Q, Yue L, Chen F, Zhang Z. Small RNA Profiles of Serum Exosomes Derived From Individuals With Latent and Active Tuberculosis. Front Microbiol. 2019 May 28;10:1174.

14. Shen D#, Ma G#, Li C#, Jia X#, Qin C#, Yang T, Wang L, Jiang X, Ding N, Zhang X, Yue L, Yin Z, Zeng L, Zhao Y, Zhou D, Chen F. Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare blaCTX-M-24-Harboring Virulence Plasmid. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02273-18.

15. Yang T#, Zhong J#, Zhang J#, Li C#, Yu X, Xiao J, Jia X, Ding N, Ma G, Wang G, Yue L, Liang Q, Sheng Y, Sun Y, Huang H, Chen F. Pan-Genomic Study of Mycobacterium tuberculosis Reflecting the Primary/Secondary Genes, Generality/Individuality, and the Interconversion Through Copy Number Variations. Front Microbiol. 2018 Aug 17;9:1886.

16. Zhang F#, Yue L#, Fang X#, Wang G#, Li C#, Sun X, Jia X, Yang J, Song J, Zhang Y, Guo C, Ma G, Sang M, Chen F, Wang P. Altered gut microbiota in Parkinson's disease patients/healthy spouses and its association with clinical features. Parkinsonism Relat Disord. 2020 Dec;81:84-88.

17. Jia X, Yang L, Li C, Xu Y, Yang Q, Chen F. Combining comparative genomic analysis with machine learning reveals some promising diagnostic markers to identify five common pathogenic non-tuberculous mycobacteria. Microb Biotechnol. 2021 Jul;14(4):1539-1549.

18. Su D, Jiao Z, Li S, Yue L, Li C, Deng M, Hu L, Dai L, Gao B, Wang J, Zhang H, Xiao H, Chen F, Yang H, Zhou D. Spatiotemporal single-cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage. Exploration (Beijing). 2023 Apr 10;3(3):20220171.

19. Zhang M, Wang P, Li C, Segev O, Wang J, Wang X, Yue L, Jiang X, Sheng Y, Levy A, Jiang C, Chen F. Comparative genomic analysis reveals differential genomic characteristics and featured genes between rapid- and slow-growing non-tuberculous mycobacteria. Front Microbiol. 2023 Sep 21;14:1243371.

20. Liu Y, Lu T, Li C, Wang X, Chen F, Yue L, Jiang C. Comparative transcriptome analysis of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E identifying potential IFN/ISGs targets for inhibiting virus replication. Front Med (Lausanne). 2023 Dec 8;10:1267903.

21. Zhu L, Zhong J, Jia X, Liu G, Kang Y, Dong M, Zhang X, Li Q, Yue L, Li C, Fu J, Xiao J, Yan J, Zhang B, Lei M, Chen S, Lv L, Zhu B, Huang H, Chen F. Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio single-molecule real-time (SMRT) technology. Nucleic Acids Res. 2016 Jan 29;44(2):730-43.

22. Fu J, Zhang J, Yang L, Ding N, Yue L, Zhang X, Lu D, Jia X, Li C, Guo C, Yin Z, Jiang X, Zhao Y, Chen F, Zhou D. Precision Methylome and In Vivo Methylation Kinetics Characterization of Klebsiella pneumoniae. Genomics Proteomics Bioinformatics. 2022 Apr;20(2):418-434.

23. Hu X, Wang J, Ju Y, Zhang X, Qimanguli W, Li C, Yue L, Tuohetaerbaike B, Li Y, Wen H, Zhang W, Chen C, Yang Y, Wang J, Chen F. Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis. BMC Infect Dis. 2022 Aug 25;22(1):707.

24. Ju Y, Jin C, Chen S, Wang J, Li C, Wang X, Wang P, Yue L, Jiang X, Tuohetaerbaike B, Li Y, Sheng Y, Qimanguli W, Wang J, Chen F. Proteomic analyses of smear-positive/negative tuberculosis patients uncover differential antigen-presenting cell activation and lipid metabolism. Front Cell Infect Microbiol. 2023 Oct 16;13:1240516.

25. Wei Y, Fu J, Wu J, Jia X, Zhou Y, Li C, Dong M, Wang S, Zhang J, Chen F. Bioinformatics Analysis and Characterization of Highly Efficient Polyvinyl Alcohol (PVA)-Degrading Enzymes from the Novel PVA Degrader Stenotrophomonas rhizophila QL-P4. Appl Environ Microbiol. 2017 Dec 15;84(1):e01898-17.

1. 国家自然科学基金，青年科学基金项目，基于空间多组学解析MIF调控免疫代谢驱动结核肉芽肿微环境异质性分化的研究，2024.01-2026.12，在研，主持；

2. 中国科学院人才项目，中国科学院青年创新促进会，2022.01-2025.12，在研，主持；

3. 国家重点研发计划，“政府间国际科技创新合作”重点专项项目，基于微生物组的抗菌因子鉴定并通过新型递送载体用于胞内结核杆菌的清除，2023.12-2025.11，在研，任务负责人；

4. 国家重点研发计划，生物安全专项项目，2019.12-2022.12，结题，子课题负责人；