学 术 报 告

　　报告题目： Single Cell Gene Therapy and Analysis on Nano-electroporation Chip

　　报告人：常凌乾

　　北京航空航天大学 生物与医院工程学院，教授

　　主持人：蒋岚 研究员

　　时 间：2019年4月23日（星期二）下午14:00-15:30

　　地 点：中国科学院北京基因组研究所一层报告厅

　　报告人简介：

　　常凌乾博士，2016年博士毕业于美国俄亥俄州立大学生物医学工程系，现为北京航空航天大学生物与医学工程学院和医工交叉高精尖中心单细胞分析纳米技术研究所教授。曾担任美国北德克萨斯大学(University of North Texas)生物医学工程系助理教授。 常凌乾博士的研究方向：单细胞基因转染技术和细胞微操纵技术及其在细胞基因检测、治疗等领域的研究。近五年在国际期刊发表SCI论文50篇，如Nature Nanotechnology, Nano Letters, Small等。申请或授权美国专利3项，中国专利3项。获得了诸多科研奖励和荣誉，如俄亥俄州立大学2015年博士最高奖Presidential Fellowship，北德克萨斯大学RSG Awards, MINE 2018‘杰出青年科学家’提名奖等。兼任SCI期刊Biomedical Engineering Online副主编（Associate Editor）和Computers in Biology and Medicine编委(Editorial Board)，Nature Springer《Electroporation Protocol》第三版主编，中国生物医学工程学会纳米医药分会青年委员。

　　Abstract:

　　One of the cutting-edge multidisciplinary research themes in Biomedical Engineering is to design and manufacture advanced Bio-Chip for life science, ranging from in vitro cell biology toward in vivo medicine. In recent years, nanotechnologies facilitate the development of bio-chips and devices which have demonstrated unprecedented capabilities in single cell analysis and manipulation. In this talk, a novel nano-biotechnology, nano-electroporation (NEP), is introduced with emphasis on high-throughput, and precisely delivery of gene / drugs into living cells at single-cell resolution.

　　The in vitro applications of the NEP platform have been demonstrated in the studies of intracellular cancer biomarker heterogeneity in leukemic cells, cardiomyocytes, T lymphocytes and glioma stem cells. Our latest efforts have achieved in vivo cell reprogramming for on-body gene therapy and wound healing. The future research of this nano-technique for flexible wearable drug delivery platform with the aims to patient-specific gene therapy and regenerative medicine are discussed.

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